Phenothiazine Tranquilizers :

The most commonly used phenothiazines in veterinary medicine are acepromazine, chlorpromazine, and promazine. In domestic animals, they are used as tranquilizers, preanesthetic agents, antiemetics, and for the treatment of CNS agitation following specific drug overdoses (amphetamines, cocaine).

Mode of action:

 Exact mechanism however scientist believe the blocking the action of dopamine in the brain. Dopamine is a neurotransmitter (chemical) that nerves use to communicate with one another.

Clinical signs:

The most common signs of overdose are sedation, weakness, ataxia, collapse, behavioral changes, hypothermia, hypotension, tachycardia, and bradycardia.

Treatment:

Treatment consists of symptomatic and supportive care. Due to rapid onset of CNS signs, emesis should only be attempted in a recent exposure and should be followed by administration of activated charcoal and a cathartic. Repeated doses of activated charcoal may be helpful, especially for large ingestions.

Hypotension should be treated with IV fluids.

Dopamine may be used if fluid administration does not correct hypotension.

Body temperature, heart rate, and blood pressure should be monitored and treated symptomatically.