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Toxicology of drugs
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Toxicity of anesthetics:(Tranquilizers,Sedatives,hypnotics)
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Toxicity of CNS stimulants
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                                                            Calcium

Source:

Seed, beans and lentils                       

– Almonds

Leaves of some plants like Solanum malacoxylon, Cestrum diurnum

– Soyanbean

– Rodenticides

– Blacberries, Strawberries.

 

Mode of transmission:

Swallowing

 

Calcification (accumulation of calcium) of bones and soft tisssues

Interfere with the absorption of other minerals line Zn, P ec.

  1. MECHANISM OF ACTION:

 

 

 

 

Hypercalcemia(high ca level in blood)

 

 

Clinical Signs:

– Excessive thirst and excessive urination

– Stomach pain and digestive problems 

– Bone pain and muscle weakness

– Confusion, lethargy and fatigue

– Anxiety and depression

– Abnormal P absorption and irregular heart rhythm.

 

Diagnosis :

Urine, faecal and blood test .

 

Treatment:

-Cinacalcet(senispar)

– Biphosphates, intravenous osteoporosis drugs

– Calcitonin

– Calcimimetics

– Denosunam

– Predinosone

– IV fluids and diuretics.

Differential Diagnosis:

– Hyperkalemia

– Hypernatremia

– Hyperparathyroidism

– Hyperphosphatemia

– Hypocalcaemia.

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